Cytokine/Chemokine HLDA8 Workshop panel report: analysis of receptors on lymphocytes from cord blood, normal and asthmatic subjects, and HIV positive patients.
Identifieur interne : 00F192 ( Main/Exploration ); précédent : 00F191; suivant : 00F193Cytokine/Chemokine HLDA8 Workshop panel report: analysis of receptors on lymphocytes from cord blood, normal and asthmatic subjects, and HIV positive patients.
Auteurs : Maria Paola Loria [Italie] ; Porzia Dambra ; Laura Capuzzimati ; Adriana Dell'Osso ; Rossella Crollo ; Giacoma De Tullio ; Elena Lasaracina ; Alfredo TursiSource :
- Cellular immunology [ 0008-8749 ]
Descripteurs français
- KwdFr :
- Adulte, Anticorps monoclonaux, Asthme (métabolisme), Humains, Infections à VIH (métabolisme), Lymphocytes (métabolisme), Récepteurs CCR5 (métabolisme), Récepteurs CCR7, Récepteurs CXCR4 (métabolisme), Récepteurs aux chimiokines (métabolisme), Récepteurs aux cytokines (métabolisme), Sang foetal (métabolisme), Syndrome d'immunodéficience acquise (métabolisme).
- MESH :
English descriptors
- KwdEn :
- Acquired Immunodeficiency Syndrome (metabolism), Adult, Antibodies, Monoclonal, Asthma (metabolism), Fetal Blood (metabolism), HIV Infections (metabolism), Humans, Lymphocytes (metabolism), Receptors, CCR5 (metabolism), Receptors, CCR7, Receptors, CXCR4 (metabolism), Receptors, Chemokine (metabolism), Receptors, Cytokine (metabolism).
- MESH :
- chemical , metabolism : Receptors, CCR5, Receptors, CXCR4, Receptors, Chemokine, Receptors, Cytokine.
- chemical : Antibodies, Monoclonal, Receptors, CCR7.
- metabolism : Acquired Immunodeficiency Syndrome, Asthma, Fetal Blood, HIV Infections, Lymphocytes.
- Adult, Humans.
Abstract
Chemokines and cytokines are involved in many processes, both physiological and pathological, particularly the recruitment, differentiation, activation, and proliferation of immune cells taking part in ontogenesis, inflammation, and cancer. It was assumed that chemokines and cytokines receptors are expressed in a regulated manner by human lymphocytes during ontogeny and later on, under the environmental stimulation of antigens they contribute to organogenesis, angiogenesis, and tissue remodeling, as well as modulating leukocyte effector functions. Using monoclonal antibodies classified by the Cytokine/Chemokine section of the 8th International Workshop on Human Leukocyte Differentiation Antigens, we analyzed human lymphocytes in blood samples drawn from the umbilical cord, normal adults, allergic and non-allergic asthma patients, HIV infected, and AIDS positive subjects. The main differences noted between adult and cord blood lymphocytes were related to CCR7 and CXCR4 receptors, which were more strongly expressed on cord blood lymphocytes, confirming the important role of these chemokines during development of the immune system. As with the HIV, CXCR4, and CCR5 co-receptors, we found no differences in CXCR4 expression between HIV and AIDS patients. However CCR5 was more strongly expressed in AIDS patients, which is likely to be associated with the evolution of disease. Further studies are needed to gain a better understanding of the functions of these molecules in the underlying pathogenesis of many diseases and to probe the use of the chemokine receptors as targets for therapeutic intervention.
DOI: 10.1016/j.cellimm.2005.08.015
PubMed: 16185672
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000163
- to stream PubMed, to step Curation: 000163
- to stream PubMed, to step Checkpoint: 000187
- to stream Ncbi, to step Merge: 000024
- to stream Ncbi, to step Curation: 000024
- to stream Ncbi, to step Checkpoint: 000024
- to stream Main, to step Merge: 00FA85
- to stream Main, to step Curation: 00F192
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cytokine/Chemokine HLDA8 Workshop panel report: analysis of receptors on lymphocytes from cord blood, normal and asthmatic subjects, and HIV positive patients.</title><author><name sortKey="Loria, Maria Paola" sort="Loria, Maria Paola" uniqKey="Loria M" first="Maria Paola" last="Loria">Maria Paola Loria</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Medicine, Immunology and Infectious Diseases, Section of Allergy and Clinical Immunology, University of Bari, Italy. mp.loria@allergy.uniba.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical Medicine, Immunology and Infectious Diseases, Section of Allergy and Clinical Immunology, University of Bari</wicri:regionArea><wicri:noRegion>University of Bari</wicri:noRegion></affiliation></author><author><name sortKey="Dambra, Porzia" sort="Dambra, Porzia" uniqKey="Dambra P" first="Porzia" last="Dambra">Porzia Dambra</name></author><author><name sortKey="Capuzzimati, Laura" sort="Capuzzimati, Laura" uniqKey="Capuzzimati L" first="Laura" last="Capuzzimati">Laura Capuzzimati</name></author><author><name sortKey="Dell Osso, Adriana" sort="Dell Osso, Adriana" uniqKey="Dell Osso A" first="Adriana" last="Dell'Osso">Adriana Dell'Osso</name></author><author><name sortKey="Crollo, Rossella" sort="Crollo, Rossella" uniqKey="Crollo R" first="Rossella" last="Crollo">Rossella Crollo</name></author><author><name sortKey="De Tullio, Giacoma" sort="De Tullio, Giacoma" uniqKey="De Tullio G" first="Giacoma" last="De Tullio">Giacoma De Tullio</name></author><author><name sortKey="Lasaracina, Elena" sort="Lasaracina, Elena" uniqKey="Lasaracina E" first="Elena" last="Lasaracina">Elena Lasaracina</name></author><author><name sortKey="Tursi, Alfredo" sort="Tursi, Alfredo" uniqKey="Tursi A" first="Alfredo" last="Tursi">Alfredo Tursi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2005 Jul-Aug</MedlineDate></PubDate></date><idno type="doi">10.1016/j.cellimm.2005.08.015</idno><idno type="RBID">pubmed:16185672</idno><idno type="pmid">16185672</idno><idno type="wicri:Area/PubMed/Corpus">000163</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000163</idno><idno type="wicri:Area/PubMed/Curation">000163</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000163</idno><idno type="wicri:Area/PubMed/Checkpoint">000187</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000187</idno><idno type="wicri:Area/Ncbi/Merge">000024</idno><idno type="wicri:Area/Ncbi/Curation">000024</idno><idno type="wicri:Area/Ncbi/Checkpoint">000024</idno><idno type="wicri:doubleKey">0008-8749::Loria M:cytokine:chemokine:hlda</idno><idno type="wicri:Area/Main/Merge">00FA85</idno><idno type="wicri:Area/Main/Curation">00F192</idno><idno type="wicri:Area/Main/Exploration">00F192</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cytokine/Chemokine HLDA8 Workshop panel report: analysis of receptors on lymphocytes from cord blood, normal and asthmatic subjects, and HIV positive patients.</title><author><name sortKey="Loria, Maria Paola" sort="Loria, Maria Paola" uniqKey="Loria M" first="Maria Paola" last="Loria">Maria Paola Loria</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Medicine, Immunology and Infectious Diseases, Section of Allergy and Clinical Immunology, University of Bari, Italy. mp.loria@allergy.uniba.it</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical Medicine, Immunology and Infectious Diseases, Section of Allergy and Clinical Immunology, University of Bari</wicri:regionArea><wicri:noRegion>University of Bari</wicri:noRegion></affiliation></author><author><name sortKey="Dambra, Porzia" sort="Dambra, Porzia" uniqKey="Dambra P" first="Porzia" last="Dambra">Porzia Dambra</name></author><author><name sortKey="Capuzzimati, Laura" sort="Capuzzimati, Laura" uniqKey="Capuzzimati L" first="Laura" last="Capuzzimati">Laura Capuzzimati</name></author><author><name sortKey="Dell Osso, Adriana" sort="Dell Osso, Adriana" uniqKey="Dell Osso A" first="Adriana" last="Dell'Osso">Adriana Dell'Osso</name></author><author><name sortKey="Crollo, Rossella" sort="Crollo, Rossella" uniqKey="Crollo R" first="Rossella" last="Crollo">Rossella Crollo</name></author><author><name sortKey="De Tullio, Giacoma" sort="De Tullio, Giacoma" uniqKey="De Tullio G" first="Giacoma" last="De Tullio">Giacoma De Tullio</name></author><author><name sortKey="Lasaracina, Elena" sort="Lasaracina, Elena" uniqKey="Lasaracina E" first="Elena" last="Lasaracina">Elena Lasaracina</name></author><author><name sortKey="Tursi, Alfredo" sort="Tursi, Alfredo" uniqKey="Tursi A" first="Alfredo" last="Tursi">Alfredo Tursi</name></author></analytic><series><title level="j">Cellular immunology</title><idno type="ISSN">0008-8749</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acquired Immunodeficiency Syndrome (metabolism)</term><term>Adult</term><term>Antibodies, Monoclonal</term><term>Asthma (metabolism)</term><term>Fetal Blood (metabolism)</term><term>HIV Infections (metabolism)</term><term>Humans</term><term>Lymphocytes (metabolism)</term><term>Receptors, CCR5 (metabolism)</term><term>Receptors, CCR7</term><term>Receptors, CXCR4 (metabolism)</term><term>Receptors, Chemokine (metabolism)</term><term>Receptors, Cytokine (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Anticorps monoclonaux</term><term>Asthme (métabolisme)</term><term>Humains</term><term>Infections à VIH (métabolisme)</term><term>Lymphocytes (métabolisme)</term><term>Récepteurs CCR5 (métabolisme)</term><term>Récepteurs CCR7</term><term>Récepteurs CXCR4 (métabolisme)</term><term>Récepteurs aux chimiokines (métabolisme)</term><term>Récepteurs aux cytokines (métabolisme)</term><term>Sang foetal (métabolisme)</term><term>Syndrome d'immunodéficience acquise (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, CCR5</term><term>Receptors, CXCR4</term><term>Receptors, Chemokine</term><term>Receptors, Cytokine</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Receptors, CCR7</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Acquired Immunodeficiency Syndrome</term><term>Asthma</term><term>Fetal Blood</term><term>HIV Infections</term><term>Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Asthme</term><term>Infections à VIH</term><term>Lymphocytes</term><term>Récepteurs CCR5</term><term>Récepteurs CXCR4</term><term>Récepteurs aux chimiokines</term><term>Récepteurs aux cytokines</term><term>Sang foetal</term><term>Syndrome d'immunodéficience acquise</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Anticorps monoclonaux</term><term>Humains</term><term>Récepteurs CCR7</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chemokines and cytokines are involved in many processes, both physiological and pathological, particularly the recruitment, differentiation, activation, and proliferation of immune cells taking part in ontogenesis, inflammation, and cancer. It was assumed that chemokines and cytokines receptors are expressed in a regulated manner by human lymphocytes during ontogeny and later on, under the environmental stimulation of antigens they contribute to organogenesis, angiogenesis, and tissue remodeling, as well as modulating leukocyte effector functions. Using monoclonal antibodies classified by the Cytokine/Chemokine section of the 8th International Workshop on Human Leukocyte Differentiation Antigens, we analyzed human lymphocytes in blood samples drawn from the umbilical cord, normal adults, allergic and non-allergic asthma patients, HIV infected, and AIDS positive subjects. The main differences noted between adult and cord blood lymphocytes were related to CCR7 and CXCR4 receptors, which were more strongly expressed on cord blood lymphocytes, confirming the important role of these chemokines during development of the immune system. As with the HIV, CXCR4, and CCR5 co-receptors, we found no differences in CXCR4 expression between HIV and AIDS patients. However CCR5 was more strongly expressed in AIDS patients, which is likely to be associated with the evolution of disease. Further studies are needed to gain a better understanding of the functions of these molecules in the underlying pathogenesis of many diseases and to probe the use of the chemokine receptors as targets for therapeutic intervention.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Capuzzimati, Laura" sort="Capuzzimati, Laura" uniqKey="Capuzzimati L" first="Laura" last="Capuzzimati">Laura Capuzzimati</name><name sortKey="Crollo, Rossella" sort="Crollo, Rossella" uniqKey="Crollo R" first="Rossella" last="Crollo">Rossella Crollo</name><name sortKey="Dambra, Porzia" sort="Dambra, Porzia" uniqKey="Dambra P" first="Porzia" last="Dambra">Porzia Dambra</name><name sortKey="De Tullio, Giacoma" sort="De Tullio, Giacoma" uniqKey="De Tullio G" first="Giacoma" last="De Tullio">Giacoma De Tullio</name><name sortKey="Dell Osso, Adriana" sort="Dell Osso, Adriana" uniqKey="Dell Osso A" first="Adriana" last="Dell'Osso">Adriana Dell'Osso</name><name sortKey="Lasaracina, Elena" sort="Lasaracina, Elena" uniqKey="Lasaracina E" first="Elena" last="Lasaracina">Elena Lasaracina</name><name sortKey="Tursi, Alfredo" sort="Tursi, Alfredo" uniqKey="Tursi A" first="Alfredo" last="Tursi">Alfredo Tursi</name></noCountry><country name="Italie"><noRegion><name sortKey="Loria, Maria Paola" sort="Loria, Maria Paola" uniqKey="Loria M" first="Maria Paola" last="Loria">Maria Paola Loria</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Lorraine/explor/InforLorV4/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00F192 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 00F192 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Lorraine
|area= InforLorV4
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:16185672
|texte= Cytokine/Chemokine HLDA8 Workshop panel report: analysis of receptors on lymphocytes from cord blood, normal and asthmatic subjects, and HIV positive patients.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:16185672" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a InforLorV4
| This area was generated with Dilib version V0.6.33. |  |